Oncomine™ Comprehensive Assay Plus - Complete CGP test, now on the Genexus™ system

Introducing an integrated, end-to-end solution for Comprehensive Genomic Profiling (CGP), available directly in your laboratory. Using Ion Torrent™ technology, the Oncomine™ Comprehensive Assay Plus kit enables rapid and efficient detection of a wide range of genetic alterations across 517 genes.

What can you detect?

Alterations in 517 genes – SNVs, indels, CNVs (gains and losses; e.g., homozygous/heterozygous amplifications), and gene fusions (over 1,300 isoforms from 49 driver genes).
Genomic signatures – homologous recombination deficiency (HRD), tumor mutational burden (TMB), and microsatellite instability (MSI), assessed with high precision based on deep coverage and dedicated algorithms (Genomic Instability Metric – GIM – for HRD: numerical scale from 0 to 100).

Clinically validated accuracy

SNVs: sensitivity ~98–99 %, specificity ~99 %
Indels and fusions: ~98 % each
CNV gain (≥8 copies): sensitivity ~99.6 %, specificity ~99.9 %
MSI: >99 % concordance
TMB: correlation r² ≈ 0.945 compared to exome-based standards

Fast and automated workflow

Only 20 minutes hands-on time, with two operator touchpoints
Complete sample-to-report workflow using two instruments:
- Genexus™ Purification System – automated extraction and quantification (2–5 h)
- Genexus™ Integrated Sequencer (Ion GX7 chip) – library prep, sequencing, and analysis
Reports generated in under 5 minutes
Total duration: approx. 5h for extraction + 26h for sequencing, with up to 4 runs/week (16 samples)
Requires just 20–30 ng DNA and 20 ng RNA (e.g., one FFPE slide), even from the first sample

All-in-one solution from a single provider

Instruments, consumables, analytics software (Oncomine Reporter), and support
Suitable for both translational medicine applications and preclinical cancer research

Why implement it?

Speed – “Next-day” CGP results, enabling maximum flexibility and rapid decisions
Validated reliability – ~94 % success rate on FFPE samples, with high sensitivity and specificity
Comprehensive insights – from point mutations to gene fusions, actionable biomarkers, and genomic instability markers
Operational efficiency – JAVA-like automated workflow, saving both time and costs

Regardless of your level of NGS experience, the Genexus™ system simplifies the implementation of in-house CGP with consistent performance and enhanced operational efficiency.

Oncomine™ Comprehensive Assay Plus – Complete CGP test, now on the Genexus™ system